2020/9/24  
Scientists find antibody that inhibits novel coronavirus by up to 98% (2020/06/03)
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  • 英文 English 
    Scientists find antibody that inhibits novel coronavirus by up to 98% (2020/06/03)

    Taiwan scientists have found an antibody that works against all four major coronavirus strains, inhibiting them by 90 to 98%. They believe the antibody can be developed into a treatment for COVID-19. The research team at Chang Gung University is seeking private sector partners for further testing and development. They're looking to transfer the technology to partner companies as early as June.

    Medical technologists put on protective gear before they enter this lab at Chang Gung Memorial Hospital. In April, a team of scientists identified 25 monoclonal antibodies in patients infected with COVID-19. During lab experiments, one proved more potent than the rest. This antibody was able to prevent the novel coronavirus from entering human cells, according to Shih Shin-ru, director of the Research Center for Emerging Viral Infections at Chang Gung University. It was able to inhibit the virus by 90 to 98%.

    Shih Shin-ru
    Chang Gung University researcher
    We can use this antibody as a detection purpose or therapeutic purpose. Because the antibody can inhibit the invasion, so we can use treatment purpose because if we inject antibody into the patient, it stops virus go further to amplify in another cell.

    Scientists found that this antibody worked against all four major strains of the novel coronavirus. These are the Chinese strain, the U.S. strain, the strain dominant in Europe, and one from Egypt.

    Huang Chiung-kuei
    Linkou Chang Gung Memorial Hospital
    It showed very good inhibitory effects against the Wuhan strain and the strain from Europe, United States and Egypt. The effect reached 90 to 98%.

    Researchers believe this antibody is a prime candidate for COVID treatment development. Because it is part of the body’s natural defense system, a drug made with this antibody has the potential to be safer than other types of treatment.

    Yang Cheng-ta
    Linkou Chang Gung Hospital
    This antibody is made from antibodies that the body naturally produces. So in the future if used as treatment, not only is it specialized, it will not affect normal cells. It is safer than therapies that use animal antibodies.

    Researchers say that antibody drugs tend to be fairly safe and to cause relatively few side effects. They also take less time to develop into a viable product. A patent is pending on this key antibody. Scientists hope to transfer the technology to the private sector as early as June.

    中文 Chinese  
    長庚發現超強抗體 抑制病毒能力高達98%

    台灣再發現抗疫新利器!長庚醫院團隊,從確診個案中,找到一株具有潛力的單株抗體,能夠有效抑制武漢肺炎病毒能力,高達90%到98%,目前正在申請專利,預計本月技轉,力拼抗體藥物,能在年底上市。

    醫事檢驗師戴上防護裝備,進入長庚醫院實驗室,4月時,他們從武漢肺炎患者身上,找出25株有效抗體,而現在研究團隊還找到了另一種更有效的單株抗體。長庚大學新興感染研究中心主任施信如表示,這種抗體能夠阻止新冠病毒進入人體細胞,效果可以達到90%到98%。

    [[長庚大學新興感染研究中心主任 施信如]]
    "我們可以將該抗體用在檢測或治療上。抗體可以抑制病毒入侵,可以利於治療,如果將抗體注入患者體內,它可以阻止病毒在另一個細胞中擴增。"

    研究人員發現,該抗體可對抗四個主要的新冠病毒菌株,包括中國菌株、美國菌株、歐洲主要株菌以及埃及菌株。

    [[林口長庚醫院檢驗醫學部副主任 黃瓊瑰]]
    "武漢株還有我們從歐洲跟美國,跟埃及來源的這個病毒株,都有很好的抑制效果,那效果可以達到90到98%"

    研究人員認為,該抗體將來可用來開發武肺治療藥物,因為它是來自於人體自癒系統,製成的藥物可能比其他類型的治療方法更安全。

    [[林口長庚醫院執行副院長 楊政達]]
    "由於這個抗體是從人體中來的病毒抗體,所以將來用來治療,不但具有專一性,也不會影響到正常細胞,安全性比動物抗體來講高很多"

    抗體藥物,來自人類的抗體物質,不但安全性高、也可以降低副作用產生、縮短藥物研發時間。而最新發現的單株抗體,也正在申請專利,希望能盡速展開技轉。


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